Seminar announcement: Franziska Knolle (Munich), 3 July 2025
Title: From Risk to Disorder: Decision-Making Dysfunctions in Psychosis.
Abstract
Alterations in decision-making are proposed to underlie several psychiatric disorders, such as psychosis. Decision-making involves integrating information about future outcomes, such as their probability, reward value, and effort cost. This process is shaped by the comparison between expected and actual outcomes, commonly described in terms of prediction errors. In psychosis, aberrant prediction error signalling is thought to bias belief formation toward unlikely or implausible outcomes, contributing to hallucinations and delusions. Additionally, impairments in decision-making have been linked to negative symptoms, particularly motivational deficits. I will present evidence for these alterations across different cohorts - from healthy adolescents with psychotic-like experiences to individuals with chronic schizophrenia - using a range of tasks, including an orthogonalised Go/No-Go task, the Two-Step task, and the Balloon Analogue Risk task combined with computational modelling. These behavioural measures offer scalable, cost-effective tools for probing mechanisms underlying psychotic symptoms.
Zoom link:
https://uni-bonn.zoom.us/j/67862809703?pwd=WHM3b3lIUFJYY2x0ekxLZUhxS3UvUT09
Meeting-ID: 678 6280 9703, Code: 193789
About the seminar series:
This seminar is part of the Bonn-Melbourne Seminar Series in Decision Neuroscience and Computational Psychiatry, jointly organised by the University of Bonn (Institute of Psychology) and the University of Melbourne (Centre for Brain, Mind and Markets).
Convenors: Professor Ulrich Ettinger (University of Bonn), Professor Carsten Murawski (University of Melbourne)
#BonnMelbourneDecisionSeminar