Therapeutic Insulin Analogs – What They Can And Can't Do For The Treatment Of Diabetes
Seminar/Forum
Davis Auditorium
Walter and Eliza Hall Institute
1g Royal Parade
Insulin has now been used for almost a century to treat diabetes. It makes sense: insulin is the hormone the body lacks and its delivery to the patient overcomes that shortage. However, this view is simplistic, as insulin delivery regimes (typically injection) cannot mimic the insulin secretion profile of the healthy pancreas.
Insulin analogues have hence been developed to overcome this therapeutic shortcoming, these analogues being broadly classified into long-acting insulins (intended to mimic basal insulin concentrations) and fast-acting insulins (intended to mimic the rapid increase in insulin concentration that occurs at meal-times).
This talk will describe the molecular nature of these insulin analogues and how they relates to the structural biology of native insulin and the insulin receptor.
No registration is required.
Presenter
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Professor Mike Lawrence, Laboratory Head - Structural Biology divisionProfessor Mike Lawrence
Laboratory Head - Structural Biology division
Walter and Eliza Hall Institute of Medical Research
Professor Lawrence is a Laboratory Head in WEHI's Structural Biology Division. His research is focussed on understanding how insulin binds to its receptor and effects signalling. His research has recently led to insights that may assist in the development of ultrafast acting therapeutic insulins.
 cannot mimic the insulin secretion profile of the healthy pancreas.
Insulin analogues have hence been developed to overcome this therapeutic shortcoming, these analogues being broadly classified into longacting insulins (intended to mimic basal insulin concentrations) and fastacting insulins (intended to mimic the rapid increase in insulin concentration that occurs at mealtimes).
This talk will describe the molecular nature of these insulin analogues and how they relates to the structural biology of native insulin and the insulin receptor.
No registration is required.
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