Mathias Pessiglione (Paris)

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Elizabeth Bowman

Seminar series

Bonn-Melbourne Seminar Series in Decision Making and Computational Psychiatry

Origins and consequences of cognitive fatigue

Mathias Pessiglione

Motivation, Brain and Behavior lab, Paris Brain Institute, Pitié-Salpêtrière Hospital, Paris, France.


Despite more than a century of scientific investigations, the origins and consequences of mental fatigue have remained elusive. Here, I will suggest a neuro-metabolic explanation: fatigue signals the cost of exerting cognitive control, to prevent the accumulation of potentially toxic substances in the lateral prefrontal cortex. It therefore results in a preference for low-cost options (no wait, no effort) during economic decision-making. This theory has received empirical validation using a combination of neuroimaging and modeling techniques, in both normal work conditions and psychiatric syndromes such as burnout.

Thursday, 17 November 2022, 9:00 am CET / 7:00 pm AEDT

About the series:
The Bonn-Melbourne Seminar Series in Decision Making and Computational Psychiatry is part of the joint doctoral training and research collaboration at the intersection of decision neuroscience and computational psychiatry between the University of Bonn (spokesperson: Ulrich Ettinger) and the University of Melbourne (spokesperson: Carsten Murawski).

The online seminars take place on Thursdays at 9:00 am (CEST)/6 pm (AEDT). Talks are 45 minutes long plus 15 minutes for questions and discussion. The target audience consists of students, PhD students, postdocs and researchers from both Bonn and Melbourne who have an interest in decision-making and computational psychiatry research.

More information about the seminar series is available here:

If you wish to take part, please feel free to contact us!