436-387 Molecular Cellular & Tissue Biomechanics

Mechanical properties of macromolecules, cells and tissues. Methods for measuring the mechanical properties of these materials. Molecular basis for cell motility. Response of cells to biochemical, mechanical and electromagnetic fields. Continuum models describing soft and hard tissue mechanics. Modelling injury arising from impact. Modelling cell motility, neoplastic growth and metastasis. Modelling tumour treatment using various modalities, including drug and radiotherapy. Biomechanics of cartilage and bone. Importance of the mechanical and chemical environment in cellular differentiation and apoptosis. Structural organisation of bone and cartilage and the relation of structure to maintaining healthy tissue. Repeat mechanisms, tissue turnover and genomic responses to the mechanical and chemical environment. Overview of orthopaedic devices used for the replacement and repair of diseased tissue in the musculoskeletal system (including design, manufacture and use of various prostheses). Continuum modelling of orthopaedic devices in-vivo. When possible, mechanical properties, engineering analysis and biological processes are related to clinically important conditions like osteoporosis and osteoarthritis and the performance of prostheses in-vivo.

At the end of this subject a student should have an:

• ability to apply knowledge of basic science and engineering fundamentals;

• in-depth technical competence in at least one engineering discipline;

• ability to undertake problem identification, formulation and solution;

• ability to utilise a systems approach to design and operational performance;

• ability to function effectively as an individual and in multidisciplinary and multi-cultural teams, with a capacity to be a leader or manager as well as an effective team leader.

One 2-hour examination (60%) and two assignments of 2000 words each or equivalent (40%).