436-386 Biomaterials

Biomaterials are produced naturally by living systems, and may be manufactured to fulfil a purpose within the body. This subject provides the basis for material acceptance before any implant or device can be integrated into the biological system. Materials in the form of solids, micro and nanoparticles, layers and coatings, and porous materials will be addressed. An emphasis will be placed on the production, structure, properties and function of materials. This will provide the background to design implanted materials with the knowledge of materials (ceramics, metals, plastics, elastomers and composites), their processing and cellular reaction. Biomaterials as inert, active and resorbable bodies will be discussed. This will be followed by a discussion on biocompatibility, and cellular events during the repair of damaged tissue. Natural biomaterials produced by living systems, in dense, porous and particulate form will cover a range of natural materials covering biomineralized tissues and deposits and protein based biomaterials (keratins, silks, collagens, protein elastomers). With a knowledge of material design and natural systems, the final topic on smart materials will provide a platform into intelligent systems. This will set the scene for cutting edge devices that interact with the tissue and organs, or are modified in response to the biological environment.

• ability to apply knowledge of basic science and engineering fundamentals;

• ability to communicate effectively with members from different disciplines;

• capacity for independent critical thought, rational enquiry and self-directed learning;

• ability to function effectively as an individual and in multi-disciplinary and multi-cultural team, with the capacity to be a leader or manager as well as an effective team member;

• ability to undertake problem identification, formulation and solution using engineering or biological approaches;

• openness to new ideas and unconventional critiques of received wisdom;

• intellectual curiosity and creativity, including understanding of the philosophical and methodological bases of research activity;

• expectation of the need to undertake lifelong learning, capacity to do so.

Final exam 3-hours (50%), project report 10 pages due during semester (30%), lab report based on practical work performed during semester (15%) and mid semester quiz 1-hour (5%).