411-394 Tissue Engineering

521-225 Integrated Biomedical Science, 536-225 Integrated Biomedical Science II

History, current status and potential of tissue engineering, major materials and fabrication methods for biomaterial scaffolds, scaffold strength and degradation. Cell-surface interactions, biocompatibility and surface engineering. The influence and delivery of growth factors in tissue engineering. Scale-up issues in vitro and in vivo, quantitative aspects of tissue engineering (including cell migration, molecular transport and mechanics in-vivo). Transplantation of engineered cells and tissues, in-vivo synthesis of tissues and organs, use of pluripotent stem cells. Clinical applications of tissue engineering such as bone regeneration vascular grafts, breast reconstruction, cardiac and corneal prostheses, artificial organs (eg. pancreas).

• apply knowledge of basic science and engineering fundamentals;

• undertake problem identification, formulation and solution;

• utilise a systems approach to design and operational performance;

• function effectively as an individual and in multi-disciplinary and multi-cultural teams, with the capacity to be a leader or manager as well as an effective team.

An end-of-semester examination of three hours contributing 80% of the final assessment and an assignment not exceeding 4000 words contributing 20% of the assessment, due in the second half of the semester.