534-301 Cellular and Molecular Pharmacology

Formerly known as 534-301 Principles of Pharmacology.

Special requirements: Laboratory coat.

Experiments involving the use of animals are an essential part of this subject; exemption is not possible.

Pharmacology 534-201; exemption may be given at the discretion of the Head of Department. Physiology 536-201 and 536-211 and biochemistry 521-211 and 521-212 are highly recommended.

After completion of this subject students will have an understanding of pharmacological concepts and skills that will enhance their insight into biomedical sciences. Emphasis will be placed on the role of quantitative pharmacological analysis in the characterisation of biological systems. Topics covered include intercellular communication and signaling pathways, mechanisms of drug-receptor interactions, classification of drug receptors. The disposition of drugs in the body, drug administration, absorption and elimination, and genetically determined variability in drug action will be discussed. A major emphasis will be placed on the molecular nature and behaviour of receptors, and the exploitation of 'new biology' or biotechnology in the service of drug and receptor characterisation.

Students will gain skills in:

• critical thinking and problem solving;

• small group work;

• information gathering and report writing; and

• systematic evaluation of scientific evidence.

A 3-hour end-of-semester written examination (70%); continuous assessment of the practical component of the subject (24%); CAL tests (6%).