600-132 Biomed: Genetics & Biodiversity

• This subject is only available to Bachelor of Biomedical Science students.

• Experiments involving the use of animals are an essential part of this subject; exemption from these experiments is not possible.

• Credit cannot be gained for this subject and 600-142.

• This is a joint botany, genetics and zoology subject.

Students are expected to enrol in both 600-131 and 600-132

Topics include the genetic consequences of meiosis; inheritance; chromosomes, genes/alleles, dominance relationships, autosomal/sex-linked inheritance; one locus, blood groups, pedigree analysis, examples of human genetic disease; more than one locus, gene interaction, linkage, multifactorial/quantitative inheritance, heritability; DNA structure and function, replication, protein synthesis, mutation; genes and development; tools used for molecular genetic analysis: restriction enzymes, PCR, gel electrophoresis, aims of the Human Genome Project; recombinant DNA technology; genes in populations; human diversity, polymorphisms, selection, the theory of evolution; generation of species; biodiversity and genetic resources; model systems for biomedical research; Monera: beneficial and harmful bacteria; viruses and infectious molecules; fungal pathogens and the role of fungi in medicine; Protista: including parasitology; plants: phytochemistry, natural products chemistry, allergens and toxic plants; animals: including invertebrate parasitology, and their role as vectors of disease; evolution of chordates and vertebrates; and evolution of primates and humans.

Students will develop generic skills in:

• the recording of observations and the analysis and interpretation of data;

• the statistical analysis of genetic data;

• manipulating laboratory equipment, in particular using microscopes and gel electrophoresis;

• basic microbial techniques; and

• accessing information sources and discerning use of the world wide web.

A 3-hour written examination on theory and practical components of the subject at the end of semester, practical assessment and a mid-semester test. Satisfactory performance in the practical assessment is a hurdle requirement for passing the subject.

• W K Purves, G H Orians, H C Heller and D Sadava, Life. 6th edn, Sinaver/Freeman, 2001.