534-302 Neuropharmacology

Experiments involving the use of animals are an essential part of this subject; exemption is not possible.

534-301; exemption may be given at the discretion of the Head of Department for students wishing to take 534-302 as part of the neuroscience stream.

The teaching program will address the mechanisms of neurochemical transmission and co-transmission and the techniques used to identify transmitter substances and monitor transmitter release. Central nervous system adrenergic and cholinergic pharmacology will be discussed, in addition to peptide and amino acid neurotransmitter systems. The interaction of neuropharmacological agents such as the antidepressants at sites of chemical neurotransmission will be discussed. In the practical component of the course, students will develop skills to set up and carry out experiments using computer-based recording equipment, and learn to record and analyse the results of pharmacological experiments demonstrating the use of drugs affecting neurotransmission. Through this process, it is envisaged that students will come to appreciate the importance of good laboratory practice, including the proper handling of laboratory animals, keeping of laboratory records, and experimental design.

On completion of this subject students will be able to:

• apply scientific approaches to problem solving;

• participate effectively in group work and make clear presentations; and

• apply quantitative analysis to data and to construct a clear written report

A 2-hour end-of-semester written examination covering material presented in lectures and practicals (75%); continuous assessment throughout the practical component of the subject (25%). An oral examination may also be held for students who do not pass the written examination.