521-212 Biochemistry & Molecular Biology Part B

Not available to students enrolled in the BBiomedSc.

Biochemistry 521-211.

Metabolism and gene expression are covered to provide an understanding of contemporary work in genomics, proteomics and metabolomics. This core subject continues from 521-211 as a foundation for a career in the life sciences. The subject is also a frequent choice for double degree students The content provides a detailed coverage of central metabolic pathways and their control. Metabolic processes will be seen as the outcome of gene expression and regulation, by factors within and external to cells. The content includes expression, transcription and translation of genes to yield functional proteins; regulation of gene expression; function and regulation of pathways for the catabolic and anabolic metabolism of carbohydrates, lipids and nitrogen-containing compounds in mammalian cells; bioenergetics and mitochondrial function; photosynthesis and carbon fixation. An introduction to the field of signal transduction will describe the actions of hormones and their intracellular signalling pathways, critical to health and disease. The course is appropriate for all with interests in fundamental research, biotechnology and bioinformatics.

In addition to the specific skills gained through study of biochemistry and molecular biology, students should be able to expand from theoretical principles to practical explanations, through observing and reporting on practical work.

Computer-based assessment of knowledge gained from computer tutorials (10%); a mid-semester examination (10%); a 3-hour written examination at the end of the semester (80%).