610-332 Bio-organic Chemistry

At least one of chemistry 610-220, 610-221 OR completion of 25 points of 200-level biochemistry subjects

The course will cover the following topics:

• natural products (12 lectures): the conception, establishment and application of biosynthetic theories as they apply to steroids; polyketides; terpenoids; alkaloids;

• metabolism (12 lectures): a mechanistic, chemical and stereochemical treatment of primary metabolism; vitamins (for example, thiamine, pantothenic acid, lipoic acid) and their role as components of co-enzymes in metabolism; bioregulators such as prostaglandins, their structure and synthesis; and

• medicinal chemistry (12 lectures): drug design and structure; peptide, protein and DNA synthesis; drug-protein interactions; drug metabolism; anabolic steroids.

One 3-hour written examination at the end of semester. Assignments and tests may constitute up to 10% of the final assessment.