534-306 Drug Discovery

Note

Credit cannot be gained for both 534-306 and 534-311 prior to 1998

Credit Points

Coordinator

Prerequisites

534-301 Principles of Pharmacology; exemption may be given at the discretion of the Head of the Department. Some 2nd year Chemistry is desirable, preferably Organic Chemistry 610-220 or 610-221

Semester

Contact

Subject Description

The teaching program will introduce students to the means by which new drugs can be discovered. The lectures will cover the following topics: Historical background; choice of therapeutic target; screening; rational drug design; molecular modelling; quantitative structure-activity relationships; the emerging role of combinatorial chemistry; peptide-based drug design; recombinant proteins as drugs; novel delivery systems; in vitro and in vivo assays; high throughput assays; the impact of molecular biology on drug discovery. In the concomitant practical workshops, students will develop skills in the use of computer-aided molecular modelling to understand drug and receptor structure and how this knowledge can be applied to the design of new drugs, and examine case studies of modern drug discovery. In a 2000-word report based on the practical workshops, students will be able to integrate knowledge from different parts of the subject, reinforcing the need for a multidisciplinary approach to the discovery and development of new drugs.

Assessment

A 2-hour end-of-semester written examination; a 2000-word project report.