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Handbook 1997 : Faculty of Science : Pharmacology

534-311 Drug Discovery

Credit Points:

11

Coordinator:

Dr R A Hughes

Prerequisite/s:

Pharmacology 534-301; Some 2nd year Chemistry is desirable, preferably Organic Chemistry 610-220 /221.

Timetable:

Semester 2

Contact:

13 x 1 hour lectures, 39 hours project tutorials

Objectives:

By the end of the teaching program in Drug Discovery, the student should:

Comprehend:

  • principles of medicinal chemistry and rational drug design;

  • the fundamentals of computer-assisted molecular modelling in drug discovery;

  • how in vitro and in vivo assays for new drugs are developed;

  • how molecular biology and recombinant DNA techniques can be applied to drug discovery.

Appreciate:

  • the need for a multidisciplinary approach to the discovery and development of new drugs.

Have developed:

  • skills in the use of computer modelling to understand drug and receptor structure, and how this knowledge can be applied to the design of new drugs.

Content:

Historical background; choice of therapeutic target; screening; rational drug design; molecular modelling; quantitative structure-activity relationships; combinatorial libraries; peptide-based drug design; recombinant proteins as drugs; novel delivery systems; in vitro and in vivo assays; high throughput screening; impact of molecular biology on drug discovery.

Assessment:

A 2-hour end-of-semester written examination; a 2000 word project report (based on work carried out during the project tutorials). Weighting of the individual assessment components will be made known at the commencement of the subject.
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Handbook 1997 : Faculty of Science : Pharmacology 
Status:                   OFFICIAL 1997
Last Modified:            Wednesday March 12 3:36 pm
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Email Enquiries:          Course_Information@registrar.unimelb.edu.au
Copyright © University of Melbourne 1997.