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Handbook 1997 : Faculty of Science : Pharmacology

534-307 Toxicology

Note:

Experiments involving the use of animals are an essential part of this subject; exemption is not possible.

Credit Points:

11.0

Coordinator:

Dr R A Hughes

Prerequisite/s:

Pharmacology 534-301.

Timetable:

Semester 2

Contact:

13 x 1 hour lectures and 39 hours practical

Objectives:

By the end of the teaching program in Toxicology, the student should:

Comprehend:

  • the mechanisms by which drugs, chemicals and toxins cause cellular toxicity;

  • how cellular toxicity can lead to effects on specific target organs.

Appreciate:

  • the importance of rational and critical scientific analysis of toxicological issues;

  • the nature of animal and in vitro toxicity testing.

Have developed:

  • skills in performing toxicological investigations with small laboratory animals (rodents) according to animal ethics guidelines;

  • skills in examining mechanisms of toxicity of drugs, chemicals and toxins in vitro.

Content:

Mechanisms of toxicity; apoptosis and necrosis; free-radicals and cell damage; interaction of chemicals with DNA; carcinogens and teratogens; venoms and toxins; organ-specific toxicity (including cardiovascular system, lung, liver, kidney, nervous system, and immune system); the in vitro and in vivo toxic effects of commonly used and encountered drugs, chemicals and toxins.

Assessment:

A 2-hour end-of-semester written examination; continuous assessment of practical reports; a 1-hour computer and manual skills-based examination. Weighting of the individual assessment components will be made known at the commencement of the subject.
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Handbook 1997 : Faculty of Science : Pharmacology 
Status:                   OFFICIAL 1997
Last Modified:            Wednesday March 12 3:36 pm
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Copyright © University of Melbourne 1997.