Handbook 1996 : Faculty of Science (Volume 4 page 172)
Biochemistry subject : Next:521-321 | Prev:521-306 | Search | Help
Availability: Not available in 1996. To be offered for the first time in 1997.
Credit points: 16.0
Coordinator: Professor W H Sawyer
Prerequisite: Biochemistry and Molecular Biology 521-203 and 521-301
Contact: 26 lectures (two a week); 36 hours of practicals and workshops (6 hours every other week)
Timetable: Second semester
Objectives:
By the end of the program the student should have acquired:
- Detailed knowledge of the methods used for the determination of three dimensional structures of proteins and nucleic acids by nuclear magnetic resonance spectroscopy and X-ray crystallography;
- Detailed knowledge of spectroscopic methods for investigating the conformations and solution properties of biological macromolecules;
- An appreciation of the principles of protein molecular dynamics and the application of these principles in the investigation of protein structure and function;
- Knowledge of the theory and practice of experimental approaches to the investigation of intermolecular interactions and macromolecular recognition;
- Advanced practical skills in the use of computers and associated molecular graphics software for the analysis of protein NMR, X-ray crystallography and molecular dynamics data and the modelling of the three dimensional structures of proteins and their ligands.
Content:
Principles and practice of methods for determining the three dimensional structures of proteins and nucleic acids, including X-ray crystallography and nuclear magnetic resonance spectroscopy. Spectroscopic methods for determining the conformations of proteins and nucleic acids in aqueous solution: absorption, fluorescence and circular dichroism spectroscopy. Molecular dynamics of proteins and the principles of macromolecular recognition.
Assessment:
A 2-hour end of semester written examination (70 per cent) plus a computer-based assignment including a written report (30 per cent).
Prescribed texts:
Biochemistry subject : Next:521-321 | Prev:521-306 | Search | Help
Handbook 1996 : Faculty of Science (Volume 4 page 172)
Status: Official 1996 Date created: Oct 9 1995 Last modified: Oct 9 1995 Authorised by: Academic Registrar Email enquiries: Course_Information@registrar.unimelb.edu.au
Maintained by: Dept. of Biochemistry & Molecul.Biology, Faculty of Medicine, Dentistry and Health Sciences.
Copyright © University of Melbourne 1995,1996.