10.0 Dr D L Ebert Biochemistry and Molecular Biology 521-201 and 521-202, or Biological Chemistry 521-024. In special circumstances, the Head of the Department may permit some students who have not taken 521-202 to enrol in this subject. Second semester 26 lectures (two a week) By the end of the program the student should have acquired:

• An appreciation of the relationships between nutrients and the metabolic processes of the typical mammal;
• A general knowledge of the factors determining metabolic integration and homeostasis;
• A detailed knowledge of the mechanism of action of selected lipid soluble vitamins and adaptive responses to a variety of dietary and environmental factors;
• A detailed understanding of the role of muscle in nitrogen homeostasis and the biochemical processes governing the metabolic responses of muscle development and metabolic responses to exercise, nutritional variations, physical trauma, anabolic drugs and muscle wasting diseases;
• A detailed understanding of the regulation of lipoprotein gene expression and metabolism and lipid transport mechanisms and the role of these processes in obesity and cardiovascular disease.

Overview of whole animal nutrition and metabolism including tissue specialisation. Adaptive responses: the molecular basis for regulation of enzymes, nutrient carrier proteins and relevant cell receptors. Mechanism of action of vitamins with particular emphasis on lipid soluble vitamins. Integrated aspects of carbohydrate, lipid and amino acid metabolism and protein turnover. Overview of the structure and function of skeletal muscle with particular emphasis on muscle proteins. Maintenance of nitrogen homeostasis in response to disturbances caused by excessive feeding, starvation, physical trauma, variations in diet, and clinical disorders such as cancer and muscle wasting diseases. Muscle metabolism, including the regulation of muscle protein gene expression, metabolism and protein turnover, metabolic adjustments in the athlete, and the biochemical basis of anabolic drug use and abuse in sport. The dietary fate of lipids, lipid transport mechanisms and the regulation of lipoprotein gene expression and metabolism. The biochemical basis of obesity and cardiovascular disease and related nutritional problems as well as adaptive responses to excessive consumption of alcohol. A 2-hour end-of-semester written examination. General Biochemistry textbooks, lecture handouts and selected journal articles will be used as sources for lecture material Lecture handouts and a list of specific references will be made available at the beginning of the course 8 Dr D L Ebert. 521-024 Biological Chemistry Second semester 26 hours of lectures.